Application of microfluidics for wound healing and skin diseases: Diagnosis and treatment

Microfluidics enables the precise manipulation of fluids and bioparticles at the micro-to nanoscale using miniaturized architectures. This technology offers distinct advantages compared to conventional assays, including reduced reagent consumption, faster processing that can save hours, and high-throughput analysis, making it valuable in biomedical applications. Microfluidic devices can substantially reduce the diagnostic turnaround time for skin infections compared with conventional culture-based methods. Lately, microfluidics has emerged as a versatile platform to fabricate functional materials, targeted drug delivery systems, lab-on-a-chip and organ-on-a-chip devices, and cellular analyzers. These technologies improve transdermal drug delivery efficiency and facilitate real-time monitoring of wound biomarkers such as IL-6 and TNF-α. Unlike oncology or infectious disease diagnostics, microfluidics in wound care and skin disease management remains underexplored. This review underscores recent advancements in microfluidic systems for wound healing to deliver antimicrobials, stimulate angiogenesis, and guide tissue regeneration. Furthermore, it also highlights diagnostic microfluidics-enabled platforms for skin disease diagnosis and personalized therapy through dynamic feedback systems. The study delineates the potential of integrating microfluidics into next-generation regenerative medicine.