What does this research mean for the field?

In patients with chronic kidney disease, those with fractures exhibit a high-turnover bone phenotype characterized by lower vitamin D and calcium, higher PTH and alkaline phosphatase, and altered bone histology compared to those without fractures. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare routine bone turnover biomarkers and semi-quantitative bone histomorphometric characteristics between chronic kidney disease stage 3–4 patients with and without fractures.

September 3, 2026SAGE Open MedicineOpen Access

Bone turnover biomarkers and semi-quantitative bone histomorphometry in chronic kidney disease: Comparison between patients with and without fractures

View Full Paper

Ask AI

Bookmark

Authors

SSSushil SharmaKasturba Medical College, Manipal PSPremjit SujirManipal Academy of Higher Education PRPranav RajasekharanManipal Academy of Higher Education

Discussion

Member takes

Implication

Cross-sectional study reveals high-turnover bone phenotypes and severe mineral imbalance in chronic kidney disease fractures, highlighting routine biomarkers for risk stratification.

Key Points

To compare routine bone turnover biomarkers and semi-quantitative bone histomorphometric characteristics between chronic kidney disease stage 3–4 patients with and without fractures.
Enrolled 48 patients with stage 3–4 chronic kidney disease divided into fracture (n = 24) and non-fracture (n = 24) cohorts in a hospital-based cross-sectional study.
Measured serum levels of calcium, 25-hydroxyvitamin D, parathyroid hormone, and alkaline phosphatase alongside semi-quantitative histomorphometry from transiliac crest biopsies or intraoperative bone samples.
Fracture patients had significantly lower serum vitamin D (p = 0.007) and calcium (p = 0.005) compared to non-fracture controls.
Serum parathyroid hormone (p = 0.002) and alkaline phosphatase (p = 0.001) were significantly elevated in the fracture group.
Semi-quantitative histomorphometry in fracture cases revealed increased osteoid volume, reduced trabecular thickness, and elevated osteoblastic and osteoclastic activity.

Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/6a993612636c6408cfa7eec0 https://doi.org/10.1177/20503121261478360

View Full Paper

Ask AI

Bookmark

Implication

Cross-sectional study reveals high-turnover bone phenotypes and severe mineral imbalance in chronic kidney disease fractures, highlighting routine biomarkers for risk stratification.

Bone turnover biomarkers and semi-quantitative bone histomorphometry in chronic kidney disease: Comparison between patients with and without fractures

Discussion

Member takes

Implication

Key Points

Cite This Study

Bone turnover biomarkers and semi-quantitative bone histomorphometry in chronic kidney disease: Comparison between patients with and without fractures

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider