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September 3, 2026Formosan Journal of Musculoskeletal DisordersOpen Access

Allograft and Recycled Autograft Reconstruction Following Resection of Bone Due to Osteosarcoma: A Systematic Review of Time to Union and Complications

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Authors

PSPo-Cheng SuMWMeng–Huang WuCLChing‐Yu Lee

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Overview

Systematic review demonstrates comparable union time and complication rates between allograft and recycled autograft reconstruction in osteosarcoma patients, indicating both are viable options.

Key Points

  • To evaluate bone union times and postoperative complication rates between allograft and recycled autograft reconstruction methods following osteosarcoma resection.
  • Systematic search of PubMed, Embase, and Scopus databases for studies comparing biological reconstruction techniques.
  • Identified 6 studies encompassing 368 total patients receiving either allografts (n = 160) or recycled autografts (n = 208).
  • Pooled descriptive statistics and performed meta-analyses for time to union, nonunion, fracture, soft tissue failure, infection, and recurrence.
  • Allograft reconstruction showed a nonsignificant trend toward faster time to union compared to recycled autografts (9.01 vs. 11.23 months; mean difference: −0.92 months [95% CI: −1.89, 0.05]; P = 0.06).
  • Complication risk was similar across methods, showing no significant differences for nonunion (RR: 0.99), fracture (RR: 1.00), soft tissue failure (RR: 0.42), infection (RR: 1.52), or local recurrence (RR: 1.10).

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a993626636c6408cfa7ef8fhttps://doi.org/10.4103/fjmd.fjmd-d-25-00073
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