Polyphenol-rich jaboticaba (Myrciaria cauliflora) seed extract confers neuroprotection and extends lifespan in Drosophila through enhanced antioxidant and anti-inflammatory capacity

Myrciaria cauliflora (jaboticaba) is widely recognized for its polyphenol-rich fruit; however, its seeds are typically discarded and remain largely underexplored despite their potential bioactive value. This study investigated the effects of different extraction conditions on the phytochemical composition and bioactivity of jaboticaba seed extracts. The optimized extract exhibited potent bioactivity, characterized by high phenolic content and strong antioxidant capacity. It effectively scavenged free radicals and inhibited lipid peroxidation, while reducing reactive oxygen species (ROS) and nitric oxide (NO) production in macrophages. These antioxidant and anti-inflammatory effects were further reflected in improved survival and enhanced redox status in Drosophila melanogaster . Moreover, in an MPTP-induced Parkinson's disease mouse model, the extract attenuated oxidative stress and improved motor performance. Collectively, these findings demonstrate that jaboticaba seed extract possesses antioxidant, anti-inflammatory, and neuroprotective properties, highlighting its potential as a functional food ingredient.