69 Spatial Proteomics Profiling Identifies Prognostic Biomarkers in Papillary Renal Cell Carcinoma

Q: What does this research mean for the field?

Specific spatial cellular neighborhoods, notably those involving SMA+ cells, PD-1+ cytotoxic T lymphocytes, and pan-cytokeratin+ cells, serve as strong prognostic biomarkers for predicting recurrence and survival in papillary renal cell carcinoma. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

W Jared Brewer; Joseph Vento; Ezra Blumenthal; Eric Davis; N R Nirmala; Aguirre De Cubas; Jennifer Gordetsky; Lan Gellert; Katy Beckermann; Brian Rini; W Kimryn Rathmell; Anupama Reddy; Scott Haake

doi:10.1093/oncolo/oyag312.070

September 1, 2026The OncologistOpen Access

69 Spatial Proteomics Profiling Identifies Prognostic Biomarkers in Papillary Renal Cell Carcinoma

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Key Points

Identify spatial proteomic biomarkers and cellular neighborhood patterns that predict disease recurrence and overall survival following nephrectomy in patients with papillary renal cell carcinoma.
Assembled a tissue microarray of tumor and adjacent normal tissue from 102 patients treated at Vanderbilt University Medical Center.
Profiled specimens with a 31-plex immunofluorescence panel to map single-cell spatial interactions into 22 distinct cellular neighborhoods.
Trained cross-validated machine learning models comparing cell proportions, marker intensities, and spatial clusters, followed by validation in the TCGA KIRP dataset.
High CD8+ cytotoxic T lymphocyte abundance correlated with reduced overall survival (p = 0.005) and recurrence (p < 0.05), with high PD-1 expression showing a stronger recurrence association (p = 0.001).
Spatial neighborhood analysis demonstrated that an alpha-smooth muscle actin-positive cellular cluster was the strongest predictor of recurrence (p < 0.005).
A pan-cytokeratin-positive cellular cluster predicted favorable prognosis with significantly lower recurrence likelihood (p < 0.01), which was corroborated alongside stromal clusters in external validation data.

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Implication

Cohort study reveals spatial immune and stromal biomarkers predictive of recurrence in papillary renal cell carcinoma, highlighting targets for post-nephrectomy risk stratification.

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Brewer et al. (2026) studied this question.

synapsesocial.com/papers/6a993653636c6408cfa7f5ab https://doi.org/10.1093/oncolo/oyag312.070

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69 Spatial Proteomics Profiling Identifies Prognostic Biomarkers in Papillary Renal Cell Carcinoma

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69 Spatial Proteomics Profiling Identifies Prognostic Biomarkers in Papillary Renal Cell Carcinoma

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