Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets

To the Editor: We report on a patient with type 1 diabetes mellitus, diagnosed at 16 years of age, in whom widespread amyloid deposits developed many years later in transplanted human islets. The islets were administered through three intraportal infusions: two infusions were administered 4 months apart when the patient was 50 years of age, and one infusion was administered when he was 54 years of age.