Experimental study reveals that gut microbiome depletion alters circadian metabolic rhythms across key brain regions in mice, highlighting a gut-driven control of daily neural metabolism.
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
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Smith et al. (2022) studied this question.
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