Key result
Smoking was significantly correlated with late gadolinium enhancement extent at baseline and 12 months in patients with acute myocarditis, with LGE persisting in 96% of patients at follow-up.
Why the study?
The study investigated cardiac magnetic resonance and laboratory findings in clinically suspected acute myocarditis and re-assessed their evolution in relation to clinical parameters and smoking habits.
Does smoking correlate with worse cardiac magnetic resonance and laboratory findings in patients with acute myocarditis?
Cohort (n=68)
Does smoking correlate with worse cardiac magnetic resonance and laboratory findings in patients with acute myocarditis?
Smoking is strongly correlated with a greater extent and persistence of late gadolinium enhancement on CMR in patients with acute myocarditis, suggesting exacerbated myocardial injury.
Answers are grounded in this paper and cite their sources.
May support smoking cessation counseling in acute myocarditis; hypothesis-generating for LGE as modifiable marker pending prospective trials.
PURPOSE: The purpose is to investigate cardiac magnetic resonance and laboratory findings in patients with clinically suspected acute myocarditis and re-assess the evolution of findings in relation to clinical parameters and smoking habits. METHODS: We prospectively analyzed 68 consecutive patients (4 females, 64 males, median age 25 years) at baseline and 51 patients 12 months later with regard to age, symptoms, and signs, smoking history, cardiac troponin I, erythrocyte sedimentation rate, c-reactive protein blood levels, electrocardiography changes, and cardiac magnetic resonance findings. Statistical analysis included group comparisons and linear regression between clinical parameters and the obtained data. RESULTS: A statistically significant correlation was recorded between smoking and late gadolinium enhancement extent, both at baseline and follow-up study. Late gadolinium enhancement extent was positively associated with cardiac troponin I serum levels and c-reactive protein and negatively with left ventricular ejection fraction at baseline study. Myocardial segments 4 and 5 were most frequently involved. Late gadolinium enhancement persisted in 96% of patients with no significant extent change at 12-month follow-up, while improved. CONCLUSIONS: A strong correlation was recorded between smoking patients with acute myocarditis and extent both at baseline and follow-up cardiac magnetic resonance. Myocardial segments 4 and 5 involvement was most prevalent. Late gadolinium enhancement persisted at follow-up, its incidence was higher than that reported in other studies and did not have an impact on the patient's clinical status or cardiac function. However, longer-term follow-up is highly recommended in these patients.
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Detorakis et al. (2020) conducted a cohort in Acute myocarditis (n=68). Smoking vs. Non-smokers was evaluated on Late gadolinium enhancement extent. Smoking was significantly correlated with late gadolinium enhancement extent at baseline and 12 months in patients with acute myocarditis, with LGE persisting in 96% of patients at follow-up.
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