Key result
TAVI successfully treats severe aortic stenosis in systemic lupus erythematosus without triggering flares.
Why the study?
Although valvular heart disease is common in patients with systemic lupus erythematosus, marked aortic stenosis, particularly severe calcific aortic stenosis, is exceptionally rare.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
This case report demonstrates that high-risk transcatheter aortic valve implantation can be successfully performed without triggering a disease flare in a patient with systemic lupus erythematosus and severe calcific aortic stenosis at prohibitive surgical risk when supported by careful multidisciplinary and immunosuppressive management.
Severe calcific aortic stenosis (CAS) in patients with systemic lupus erythematosus (SLE) is exceptionally rare. SLE affects multiple organ systems, including the cardiovascular system. Cardiovascular mortality in SLE is approximately three times higher than in the general population, and cardiovascular morbidity affects about 25% of patients. Although valvular heart disease (VHD) is common in SLE, marked aortic stenosis, particularly severe CAS, remains uncommon. This case report describes a 60-year-old female patient with SLE and VHD who developed rapid progressive, severe, symptomatic CAS. A multidisciplinary heart team determined that she was at prohibitive risk for surgical aortic valve replacement, and she subsequently underwent high-risk transcatheter aortic valve implantation. No SLE flare occurred. Regular cardiovascular risk assessment and echocardiographic screening are essential for patients with SLE. Careful multidisciplinary and immunosuppressive management supports successful interventions while minimizing the risk of SLE flare.
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Omar et al. (2026) conducted a case report in Severe calcific aortic stenosis in systemic lupus erythematosus (n=1). Transcatheter aortic valve implantation was evaluated on Procedural success and absence of systemic lupus erythematosus flare. High-risk transcatheter aortic valve implantation successfully treated severe calcific aortic stenosis in a 60-year-old female with systemic lupus erythematosus with 0 post-procedural SLE flares.
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