Key result
Three cases of systemic lupus erythematosus with aortic insufficiency demonstrated varied pathology, including Libman-Sacks endocarditis, aortitis, and mucoid degeneration of a fenestrated aortic valve.
Case Report (n=3)
Aortic insufficiency in systemic lupus erythematosus can result from diverse pathologies including Libman-Sacks endocarditis, aortitis, or mucoid degeneration.
Clinicians should consider multiple pathologies causing aortic insufficiency in SLE; case reports leave open prevalence, mechanisms, and management implications.
Three cases of systemic lupus erythematosus (SLE) with aortic insufficiency are presented. One patient had Libman‐Sacks endocarditis at necropsy. Another had aortitis and pancarditis. The third had a fenestrated aortic valve showing mucoid degeneration, similar to the lesions described in Marfan's syndrome and the “floppy valve” syndrome, and had a successful insertion of a prosthetic valve. Two patients with subcutaneous “rheumatoid nodules” had persistently negative latex fixation tests.
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Shulman et al. (1969) conducted a case report in Systemic lupus erythematosus (SLE) with aortic insufficiency (n=3). Systemic lupus erythematosus (SLE) with aortic insufficiency was evaluated on Clinical and pathological findings. Three cases of systemic lupus erythematosus with aortic insufficiency demonstrated varied pathology, including Libman-Sacks endocarditis, aortitis, and mucoid degeneration of a fenestrated aortic valve.
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