Cholesterol-Lowering Effects of Isolated Soybean Protein Hydrolyzate with Bound Phospholipids in Rats.

Goro Hori; Kazuhiro Yamamoto; Koji Morishita; Saori Mukawa; Toshikazu Kamiya; Satoshi Nagaoka

doi:10.4327/jsnfs.52.135

January 1, 1999Nippon Eiyo Shokuryo GakkaishiOpen Access

Cholesterol-Lowering Effects of Isolated Soybean Protein Hydrolyzate with Bound Phospholipids in Rats.

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Key Points

To compare the cholesterol-lowering effects and intestinal absorption inhibition of three soybean protein hydrolyzate preparations with bound phospholipids in vitro and in vivo.
Evaluated three preparations: a pepsin digest high-molecular fraction (SPHP-p), a microbial protease digest high-molecular fraction (SPHP-s), and crude SPHP-s (c-SPHP).
Measured cholesterol uptake inhibition in cultured Caco-2 cells across varying preparation concentrations.
Assessed serum and liver cholesterol responses in rats fed high-cholesterol diets across both preventive (concurrent feeding) and therapeutic (reversal of established hypercholesterolemia) protocols.
Dietary addition of 20% SPHP-p dose-dependently restored elevated serum and liver cholesterol to pre-intake levels in hypercholesterolemic rats, with 5% SPHP-p lowering serum cholesterol more than cholesterol removal alone.
SPHP-s exhibited molecular weight and amino acid composition comparable to SPHP-p and inhibited Caco-2 cholesterol uptake with equal dose-dependent potency, whereas c-SPHP showed slightly weaker inhibition.
Both SPHP-p and SPHP-s demonstrated strong cholesterol-lowering efficacy in preventive and therapeutic rat models, effectively normalizing hypercholesterolemic states.

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Implication

Demonstrates that soybean protein hydrolyzates with bound phospholipids lower serum and liver cholesterol in rats, indicating suppressed intestinal cholesterol absorption.

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Hori et al. (1999) studied this question.

synapsesocial.com/papers/6a993e81ba1957220e75d20e https://doi.org/10.4327/jsnfs.52.135

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Cholesterol-Lowering Effects of Isolated Soybean Protein Hydrolyzate with Bound Phospholipids in Rats.

Key Points

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Cholesterol-Lowering Effects of Isolated Soybean Protein Hydrolyzate with Bound Phospholipids in Rats.

Key Points

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