Key result
Elderly women with major depressive disorder exhibited higher plasma IL-6 and IL-4 levels than controls, but only type 2 diabetes remained associated with MDD after adjusting for comorbidities.
Why the study?
This study aimed to investigate peripheral cytokines in elderly female patients with MDD compared to controls, and to assess the influence of clinical comorbidities on inflammatory markers.
Are plasma cytokine levels elevated in elderly women with MDD, and is this association influenced by clinical comorbidities like diabetes?
Case-Control (n=44)
Are plasma cytokine levels elevated in elderly women with MDD, and is this association influenced by clinical comorbidities like diabetes?
The association between MDD and elevated inflammatory cytokines (IL-6 and IL-4) in elderly women is significantly influenced by the presence of type 2 diabetes mellitus.
Small observational cytokine study in elderly women with MDD; leaves open inflammation's role independent of comorbidities.
OBJECTIVE: This study aimed at investigating a set of peripheral cytokines in elderly female patients with MDD, comparing them to controls, and assessing the potential influence of clinical comorbidities on inflammatory markers. METHODS: Twenty-five elderly female patients diagnosed with MDD and 19 age-matched female controls were enrolled on this study. Plasma levels of interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were evaluated with commercially-available assays. RESULTS: Elderly female patients with MDD exhibited higher plasma IL-6 and IL-4 levels when compared to controls. In a logistic regression model taking cytokine levels, comorbidities, and age into account, only type 2 diabetes mellitus (DM2) remained associated with MDD. CONCLUSION: Diabetes influences the association between MDD and higher levels of cytokines in elderly female patients. Future studies should take this evidence into account in order to mitigate confounding factors.
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Dias et al. (2022) conducted a case-control in Major Depressive Disorder (MDD) (n=44). Major Depressive Disorder vs. Age-matched healthy controls was evaluated on Plasma levels of IL-4, IL-6, IL-10, IFN-γ and TNF-α. Elderly women with major depressive disorder exhibited higher plasma IL-6 and IL-4 levels than controls, but only type 2 diabetes remained associated with MDD after adjusting for comorbidities.
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