Key result
Vitamin D deficiency appears to be involved in the pathogenesis of coronary artery disease, though large-scale randomized controlled trials are needed to prove supplementation improves outcomes.
This review highlights the potential role of Vitamin D deficiency in the pathogenesis of coronary artery disease and emphasizes the need for further research.
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May link vitamin D deficiency to CAD pathogenesis; leaves open supplementation benefit pending large RCTs.
Coronary artery disease (CAD) has become the latest scourge of humankind and referred to in this article as CAD, is the end result of the accumulation of atheromatous plaques within the walls of coronary arteries that supply the myocardium, a process also known as atherosclerosis and manifests mostly in the form of chronic stable angina or acute coronary syndrome. Vitamin D has attracted considerable interest recently due to its role in a number of extraskeletal disease processes including multiple sclerosis, malignancies, diabetes mellitus, and CAD. It is also known as sunshine vitamin due to its production in the body following exposure to ultraviolet rays, and it is a unique vitamin as it acts like a hormone with its receptor present in a wide range of tissues including endothelium, which is the important mediator of atherosclerosis and subsequent CAD. A large number of studies conducted in the past have provided the basic scientific framework and this article attempts to explore the role of Vitamin D deficiency in the pathogenesis of CAD and stresses the need for further research to fill up gap in our knowledge.
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Aggarwal et al. (2016) conducted a review in Coronary artery disease and Vitamin D deficiency. Vitamin D deficiency was evaluated. Vitamin D deficiency appears to be involved in the pathogenesis of coronary artery disease, though large-scale randomized controlled trials are needed to prove supplementation improves outcomes.
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