Key result
Lower serum bile acids linked to ~84% higher AF risk in the elderly.
Why the study?
Serum total bile acid concentration is linked to cardiovascular disease, but its association with atrial fibrillation lacks establishment.
Is fasting serum total bile acid concentration associated with atrial fibrillation prevalence in patients aged ≥75 years?
Cross-Sectional (n=522)
Is fasting serum total bile acid concentration associated with atrial fibrillation prevalence in patients aged ≥75 years?
Fasting serum total bile acid concentration exhibits an L-shaped association with atrial fibrillation risk in elderly patients, with lower levels independently predicting higher risk.
Lower bile acids associated with AF in patients ≥75 years; hypothesis-generating and should not change practice.
Serum total bile acid (BA) concentration, while linked to cardiovascular disease, lacks established associations with atrial fibrillation (AF). This cross-sectional study investigated the relationship between fasting serum total BA and AF prevalence/classification (paroxysmal vs persistent) in 522 patients aged ≥75 years. Participants were categorized by AF diagnosis and stratified by BA tertiles. Results revealed significantly lower serum total BA concentrations in AF patients compared to sinus rhythm controls. Notably, within the AF group, persistent cases exhibited lower BA levels than paroxysmal cases (3.00 (1.67–5.00) vs 3.80 (2.30–6.40) μmol/L, p = 0.005). Analysis demonstrated a nonlinear L-shaped relationship between BA and AF prevalence (inflection point: 4.08 μmol/L), with lower BA levels independently associated with higher AF risk (adjusted odds ratio = 1.84, 95% CI: (1.03–3.29), p = 0.040). These findings establish an L-shaped correlation, indicating reduced fasting serum total BA as an independent predictor for increased AF risk in the elderly.
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A 2025 study conducted a cross-sectional in Atrial fibrillation (n=522). Fasting serum total bile acids vs. Higher fasting serum total bile acid levels was evaluated on Atrial fibrillation prevalence (OR 1.84, 95% CI 1.03-3.29, p=0.040). Lower fasting serum total bile acid levels were independently associated with higher atrial fibrillation risk in the elderly (adjusted OR 1.84; 95% CI 1.03-3.29; p=0.040).
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