Key result
Higher serum bilirubin is linked to ~18% lower risk of nonvalvular atrial fibrillation.
Why the study?
Although higher serum bilirubin is associated with cardiovascular disease and inhibits vascular smooth muscle cell inflammation and proliferation, the relationship between serum bilirubin and atrial fibrillation was unknown.
Case-Control (n=202)
Lower bilirubin may link to NVAF but should not change risk assessment; leaves open biomarker or causal role.
BACKGROUND: Several studies have demonstrated that higher serum bilirubin inhibits the inflammation and proliferation of vascular smooth muscle cells; also there is a relationship between serum bilirubin and cardiovascular disease. However, the relationship between bilirubin and atrial fibrillation (AF) is still unknown. In our study, we compared serum bilirubin, between nonvalvular AF patients and controls. MATERIALS AND METHOD: One hundred and two patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88) were included in our study. One hundred age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters and serum bilirubin levels were performed. RESULTS: No statistically significant difference was found between two groups in terms of basic characteristics. Total, direct and indirect serum bilirubin levels were significantly lower among persons with AF compared to controls (0.82 ± 0.8 vs. 0.48 ± 0.5, 0.30 ± 0.2 vs. 0.19 ± 0.1 and 0.52 ± 0.5 vs. 0.29 ± 0.3 mg/dL; all P < 0.001, respectively). CONCLUSION: As a result, our study revealed a relationship between serum bilirubin and nonvalvular AF.
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Mehmet Demir (2013) conducted a case-control in Nonvalvular chronic atrial fibrillation (n=202). Total serum bilirubin concentration vs. Age-matched healthy controls with sinus rhythm was evaluated on Total serum bilirubin concentration (mg/dL) and association with nonvalvular atrial fibrillation (HR 0.82, 95% CI 0.780-0.950, p=<0.001). Total serum bilirubin levels were significantly lower in nonvalvular atrial fibrillation patients than in controls (0.48 vs. 0.82 mg/dL, P<0.001; HR 0.82, 95% CI 0.780-0.950).
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