Key result
Massive epicardial fat accumulation (487 mL) was associated with the development of constrictive pericarditis in a 59-year-old woman with end-stage renal disease.
Case Report (n=1)
Massive epicardial fat accumulation can exert a mechanical constrictive effect on the heart, especially when combined with pericardial thickening, leading to constrictive pericarditis.
May prompt evaluation of epicardial fat in ESRD-related pericardial disease; hypothesis-generating, requires confirmation in larger cohorts.
Massive deposits of fat around heart are seen in overweight persons and are associated with coronary artery disease. Investigators have focused on the clinical significance of epicardial fat with respect to metabolic effects such as insulin resistance and inflammation, but the mechanical effects, such as constriction, have been largely ignored. We present an unusual case of a 59-year-old woman with obesity and diabetes mellitus who had been undergoing peritoneal dialysis due to end-stage renal disease, and who developed constrictive pericarditis, possibly secondary to extensive epicardial fatty accumulation.
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Do et al. (2009) conducted a case report in Constrictive pericarditis (n=1). Massive epicardial fat accumulation was evaluated on Development of constrictive pericarditis. Massive epicardial fat accumulation (487 mL) was associated with the development of constrictive pericarditis in a 59-year-old woman with end-stage renal disease.
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