Key result
Recurrent and new-onset depression were associated with a significantly increased prevalence of diastolic dysfunction (63.28% and 29.31%, respectively, vs 0% in controls).
Why the study?
To evaluate the impact of depression intensity, duration, and recurrence on arterial stiffness, left ventricular hypertrophy, and diastolic dysfunction, and to identify predictors of diastolic dysfunction.
Does new-onset or recurrent depression increase the risk of arterial stiffness and diastolic dysfunction in patients without known cardiovascular disease?
Population
58 patients with NOD, 128 with RD, and 33 controls without significant heart diseases
Comparison
New onset depression vs recurrent depression vs controls without depression
Authors
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Depression severity, duration, and recurrence were associated with arterial stiffness and diastolic dysfunction; leaves open whether targeted screening or treatment modifies cardiac risk.
Cross-Sectional (n=219)
No
Does new-onset or recurrent depression increase the risk of arterial stiffness and diastolic dysfunction in patients without known cardiovascular disease?
Absolute Event Rate: 63.28% vs 0%
p-value: p=<0.001
Depression, particularly recurrent and severe forms, is independently associated with increased arterial stiffness and diastolic dysfunction in patients without known cardiovascular disease.
Tudoran et al. (2020) conducted a cross-sectional in New and recurrent depression (n=219). Depression (New-onset and Recurrent) vs. Subjects without depressive symptoms was evaluated on Prevalence of diastolic dysfunction (p=<0.001). Recurrent and new-onset depression were associated with a significantly increased prevalence of diastolic dysfunction (63.28% and 29.31%, respectively, vs 0% in controls).
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