Key result
Higher aortic stiffness was associated with major depressive disorder in men aged ≤60 years (OR 2.36; 95% CI 1.45-3.84), but not in women or older individuals.
Why the study?
Is arterial stiffness associated with major depressive disorder and depressive symptoms in middle-aged adults?
Population
2757 participants from The Maastricht Study, mean age 59.8 ± 8.1 years, 48.8% men, 27% with type 2 diabetes…
Comparison
Higher aortic stiffness measured by carotid to… vs Lower aortic stiffness
Design
Cross-sectional
Authors
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No immediate clinical implications for vascular assessment in depression; leaves open bidirectional links for longitudinal study.
Cross-Sectional (n=2,757)
Is arterial stiffness associated with major depressive disorder and depressive symptoms in middle-aged adults?
Odds Ratio: 2.36 (95% CI 1.45–3.84)
Greater aortic stiffness is associated with major depressive disorder and depressive symptoms in middle-aged men, suggesting a potential vascular link to depression in this demographic.
Onete et al. (2018) conducted a cross-sectional in Major depressive disorder and depressive symptoms (n=2,757). Aortic stiffness (carotid to femoral pulse wave velocity) vs. Lower aortic stiffness was evaluated on Major depressive disorder (MDD) in men aged 60 years or younger (OR 2.36, 95% CI 1.45-3.84). Higher aortic stiffness was associated with major depressive disorder in men aged ≤60 years (OR 2.36; 95% CI 1.45-3.84), but not in women or older individuals.
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