Key result
Protozoan parasites are genetically heterogeneous regarding the RNA interference pathway, with RNAi present in Trypanosoma brucei and Toxoplasma gondii but absent in T. cruzi and Leishmania major.
Population
Protozoan parasites
Design
Review
Authors
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Genetic heterogeneity precludes uniform RNAi tools across protozoa; leaves open species-specific functional studies before any translational use.
This review highlights the genetic heterogeneity of the RNAi pathway across different protozoan parasites, indicating its early evolutionary origin and variable presence.
Ullu et al. (2004) conducted a review in Protozoan parasite infections. RNA interference (RNAi) was evaluated. Protozoan parasites are genetically heterogeneous regarding the RNA interference pathway, with RNAi present in Trypanosoma brucei and Toxoplasma gondii but absent in T. cruzi and Leishmania major.
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