Methodological study demonstrates reductive cross-coupling of disulfides with dialkyl carbonates, highlighting a sustainable, 100% sulfur atom-economic route to diverse thioethers.
Manganese is a cheap and environmentally friendly metal on Earth. Herein, we report a manganese-promoted reductive cross-coupling using easily available and odorless disulfides as thiolating agents in an excellent 100% sulfur atom economy. The protocol featured a broad substrate scope, including various alkyl disulfides and excellent functional group compatibility, constructing diverse thioethers under simple conditions. Ultimately, thioethers can be prepared in gram-scale reactions and further transformed into structurally complex molecules.
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Zhang et al. (2023) studied this question.
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