Key result
Aortic balloon valvuloplasty fractured aortic valve calcific deposits in 3 patients examined at necropsy, suggesting this fracture is the mechanism for successful hemodynamic improvement.
Why the study?
What is the mechanism of successful aortic balloon valvuloplasty in calcific aortic stenosis?
Case Report (n=3)
What is the mechanism of successful aortic balloon valvuloplasty in calcific aortic stenosis?
Fracture of leaflet calcium represents the mechanistic basis for successful aortic balloon valvuloplasty in calcific aortic stenosis.
Supports calcium fracture as mechanism of aortic balloon valvuloplasty success in calcific AS; hypothesis-generating from 3 necropsy cases and requires prospective validation.
Balloon valvuloplasty has been shown to acutely reduce the hemodynamic and symptomatic severity of calcific aortic stenosis. The mechanism by which this improvement is accomplished is not known. At necropsy, three patients who died after hemodynamically successful aortic balloon valvuloplasty were found to have aortic valve calcific deposits fractured at one or more sites. These findings suggest that fracture of leaflet calcium represents the basis for successful aortic balloon valvuloplasty.
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Jeffrey M. Isner (1988) conducted a case report in calcific aortic stenosis (n=3). Aortic balloon valvuloplasty was evaluated on Fracture of aortic valve calcific deposits at necropsy. Aortic balloon valvuloplasty fractured aortic valve calcific deposits in 3 patients examined at necropsy, suggesting this fracture is the mechanism for successful hemodynamic improvement.
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