Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG)2 at 1.3-Å Resolution

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTMajor Groove Binding and 'DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG)2 at 1.3-Å ResolutionAlan K. Todd, Adrienne Adams, James H. Thorpe, William A. Denny, Laurence P. G. Wakelin, and Christine J. CardinView Author Information Chemistry Department, University of Reading, Whiteknights, Reading RG6 6AD, U.K., Biochemistry Department, Trinity College, Dublin 2, Ireland, Auckland Cancer Society Research Centre, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Chemistry Department, University College Dublin, Belfield, Dublin 4, Ireland Cite this: J. Med. Chem. 1999, 42, 4, 536–540Publication Date (Web):February 25, 1999Publication History Received17 August 1998Published online25 February 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/jm980479uhttps://doi.org/10.1021/jm980479urapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views992Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstract