Key result
The benefits of secondary prevention of coronary heart disease achieved with statins outweigh the hazards of statin-induced myopathy during early cardiac rehabilitation.
Why the study?
Does combining statin therapy with early cardiac rehabilitation increase the risk of myopathy in patients after acute coronary syndromes?
Does combining statin therapy with early cardiac rehabilitation increase the risk of myopathy in patients after acute coronary syndromes?
While physical exercise during cardiac rehabilitation may increase the risk of statin-induced myopathy, the cardiovascular benefits of statins outweigh these risks when exercise is gradually intensified and patients are carefully monitored.
Supports monitored statin use with gradual exercise in early post-ACS rehab; leaves open need for randomized confirmation.
The role of statins in the primary and secondary prevention of cardiovascular events is well known. An important adverse event associated with statin treatment is myopathy; intensive physical effort in patients treated with statins increases the risk of muscle injury/myopathy. In this article we discuss the benefits and risks associated with statin treatment in patients undergoing cardiac rehabilitation after acute coronary syndromes and/or coronary revascularization procedures. In our opinion, the benefits of the secondary prevention of coronary heart disease achieved with statins seem to outweigh the hazards associated with statin therapy. The careful selection of patients for both treatment with statins and the gradual intensification of physical training in the course of cardiac rehabilitation appears to constitute an important element of the therapeutic approach.
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Celiński et al. (2011) conducted a review in Hyperlipidaemia and coronary heart disease. Statins and early cardiac rehabilitation was evaluated. The benefits of secondary prevention of coronary heart disease achieved with statins outweigh the hazards of statin-induced myopathy during early cardiac rehabilitation.
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