Why a New Diagnostic Criteria for Pediatric Familial Mediterranean Fever Patients?

Familial Mediterranean fever (FMF) is a systemic auto-inflammatory disorder characterized by seemingly unprovoked recurrent episodes of fever and localized inflammation usually involving the peritoneum, pleura and joints accompanied by a marked acute-phase response. The disease primarily affects populations living around the Mediterranean basin ( Jewish, Armenian, Arab, Turkish populations) but is also scattered throughout the western world due to extensive population movements of the 20th century [1,2]. Although FMF is an ancient disease and the most common inherited Abstract