Key result
Irisin treatment significantly improved endothelial function in high-fat diet-induced obese mice by modulating the heme oxygenase-1/adiponectin axis in perivascular adipose tissue.
Why the study?
Does irisin improve endothelial dysfunction in diet-induced obese mice?
Population
Male C57BL/6 mice fed with a high-fat diet (HFD)
Comparison
Irisin treatment vs High-fat diet without irisin treatment
Design
Preclinical
Authors
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Hypothesis-generating for irisin in obesity-related endothelial dysfunction; human trials needed before any clinical consideration.
Does irisin improve endothelial dysfunction in diet-induced obese mice?
Irisin improves endothelial function in diet-induced obese mice by modulating the HO-1/adiponectin axis in perivascular adipose tissue.
Hou et al. (2017) studied Diet-induced obesity and endothelial dysfunction. Irisin vs. High-fat diet without irisin treatment was evaluated on Endothelium-dependent vasorelaxation. Irisin treatment significantly improved endothelial function in high-fat diet-induced obese mice by modulating the heme oxygenase-1/adiponectin axis in perivascular adipose tissue.
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