Key result
High kynurenic acid (OR 1.004; 95% CI 1.001-1.008; P=0.014) and 3-hydroxyanthranilic acid were independently associated with 12-month poor outcome after out-of-hospital cardiac arrest.
Why the study?
Do high levels of kynurenine pathway metabolites predict early death and poor 12-month outcome in patients resuscitated from out-of-hospital cardiac arrest?
Population
245 patients resuscitated from out-of-hospital cardiac arrest, admitted to 21 intensive care units in Finland.
Comparison
High plasma levels of kynurenine pathway… vs Lower plasma levels of kynurenine pathway…
Design
Cohort
Follow-up
12 months
Authors
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May refine post-OHCA risk stratification; hypothesis-generating and should not yet change practice.
Observational (n=245)
Yes
Do high levels of kynurenine pathway metabolites predict early death and poor 12-month outcome in patients resuscitated from out-of-hospital cardiac arrest?
Odds Ratio: 1.004 (95% CI 1.001–1.008)
p-value: p=0.014
Early activation of the kynurenine pathway is an independent predictor of early death and poor 12-month neurological outcome in patients resuscitated from out-of-hospital cardiac arrest.
Ristagno et al. (2014) conducted an observational in Out-of-Hospital Cardiac Arrest (n=245). Kynurenine pathway metabolites (kynurenic acid and 3-hydroxyanthranilic acid) vs. Lower levels of kynurenine pathway metabolites was evaluated on 12-month poor outcome (cerebral performance category 3 to 5) (OR 1.004, 95% CI 1.001 to 1.008, p=0.014). High kynurenic acid (OR 1.004; 95% CI 1.001-1.008; P=0.014) and 3-hydroxyanthranilic acid were independently associated with 12-month poor outcome after out-of-hospital cardiac arrest.
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