Key result
Poor ECOG performance status, bilateral effusion, and lack of oncological treatment after diagnosis were significantly associated with shorter survival time in patients with malignant pleural effusion.
Why the study?
What are the prognostic factors for survival in advanced cancer patients with malignant pleural effusion in a palliative care setting?
Observational (n=48)
No
What are the prognostic factors for survival in advanced cancer patients with malignant pleural effusion in a palliative care setting?
In palliative care outpatients with malignant pleural effusion, poor ECOG status, bilateral effusion, lack of oncological treatment, and lung primary tumor are associated with worse survival.
Answers are grounded in this paper and cite their sources.
LENT score may aid survival estimation in palliative MPE; leaves open prospective validation before routine adoption.
BACKGROUND: Malignant pleural effusion (MPE) has varied survival and indicates advanced disease. LENT prognostic score is the first validated score used for MPE. This study assessed the role of LENT among palliative care cancer patients and assessed different patient, tumor, and treatment related factors that may affect survival. METHODS: A retrospective study of advanced cancer patients with MPE, seen in palliative care outpatient clinic (2013-2015) until death, was done. LENT prognostic score could be calculated in 15 patients. Patient, tumor, and treatment related factors that affect survival were assessed. CONCLUSION: ECOG performance status, bilateral effusion, and no oncological treatment after diagnosis of MPE were associated with poor ST. Lung primary was associated with shorter OS and ST. Small numbers precluded any definitive conclusion on the prognostic value of LENT in our group of patients, and hence larger studies are recommended.
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Jeba et al. (2018) conducted an observational in Malignant pleural effusion (n=48). Prognostic factors (ECOG status, bilateral effusion, oncological treatment) vs. Favorable prognostic factors was evaluated on Survival time from diagnosis of malignant pleural effusion to death. Poor ECOG performance status, bilateral effusion, and lack of oncological treatment after diagnosis were significantly associated with shorter survival time in patients with malignant pleural effusion.
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