Key result
Coordinated interactions through both a- and b-epitopes strengthened monomer/fibrinogen association by an additional order of magnitude over individual epitope associations.
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May refine fibrinogen interaction models; hypothesis-generating for hemostasis therapies, with no current clinical implications.
Shainoff et al. (1983) studied Fibrin assembly and metabolism. Fibrinopeptide B release was evaluated on Monomer/fibrinogen association. Coordinated interactions through both a- and b-epitopes strengthened monomer/fibrinogen association by an additional order of magnitude over individual epitope associations.