Key result
Treatment with heparin and fresh frozen plasma led to the disappearance of the left ventricular thrombus on the fourth day, with protein C levels returning to normal after 18 weeks.
Case Report (n=1)
No
This is the first reported case of a left-sided cardiac thrombus associated with acquired protein C deficiency in a neonate, which successfully resolved with fresh frozen plasma and heparin therapy.
May support heparin and fresh frozen plasma for neonatal left ventricular thrombus with acquired protein C deficiency; hypothesis-generating and requires validation.
We present a patient with left ventricular thrombus diagnosed by two-dimensional echocardiography. Thrombosis was due to acquired transient protein C deficiency which was caused by impaired liver function due to hepatitis, sepsis and heart failure. With proper treatment the thrombus disappeared on the fourth day. Eighteen weeks later the protein C level returned to normal. We recommend echocardiographic evaluation and follow-up of suspected cases for intracardiac thrombus. The measurement of protein C level in such cases is proposed. This is the first case with left-sided cardiac thrombus associated with protein C deficiency in the medical literature.
No takes yet. Share an insight, caveat, or question.
Özkutlu et al. (1992) conducted a case report in Left ventricular thrombosis and acquired protein C deficiency (n=1). Heparin and fresh frozen plasma was evaluated on Thrombus resolution and protein C normalization. Treatment with heparin and fresh frozen plasma led to the disappearance of the left ventricular thrombus on the fourth day, with protein C levels returning to normal after 18 weeks.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: