Key result
Pressure-controlled ventilation significantly decreased mean peak airway pressure at 10 min compared to volume-controlled ventilation (20.4 vs 24.0 cmH2O, p=0.004) during laparoscopic cholecystectomy.
Why the study?
Does pressure-controlled ventilation improve airway pressures compared to volume-controlled ventilation in non-obese patients undergoing laparoscopic cholecystectomy?
RCT (n=42)
Randomized
Does pressure-controlled ventilation improve airway pressures compared to volume-controlled ventilation in non-obese patients undergoing laparoscopic cholecystectomy?
Absolute Event Rate: 20.4% vs 24%
p-value: p=0.004
Supports pressure-controlled ventilation as a safe alternative in laparoscopic cholecystectomy; extends evidence to non-obese patients.
The potential advantages of pressure-controlled over volume-controlled ventilation during laparoscopic surgery have yet to be proven. We randomly assigned 42 patients with BMI <30 kg.m(-2) scheduled for laparoscopic cholecystectomy to receive either pressure- or volume-controlled ventilation. Compared with volume-controlled ventilation, pressure-controlled ventilation resulted in a significant decrease in mean (SD) peak airway pressure at 10 min (20.4 (2.7) vs 24.0 (4.7)cmH₂O, p=0.004) and 30 min (20.7 (3.0) vs 23.9 (4.9)cmH₂O, p=0.015) and an increase in mean airway pressure at 10 min (10.5 (0.9) vs 9.6 (1.1)cmH₂O, p=0.007) and 30 min (10.5 (1.1) vs 9.6 (1.2)cmH₂O, p=0.016) after the start of surgery. Gas exchange and haemodynamic stability were similar. We conclude that pressure-controlled ventilation is a safe alternative and offers some advantages to volume-controlled ventilation during laparoscopic cholecystectomy in non-obese patients.
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Tyagi et al. (2011) conducted an RCT in Laparoscopic cholecystectomy (n=42). Pressure-controlled ventilation vs. Volume-controlled ventilation was evaluated on Mean peak airway pressure at 10 min (cmH2O) (p=0.004). Pressure-controlled ventilation significantly decreased mean peak airway pressure at 10 min compared to volume-controlled ventilation (20.4 vs 24.0 cmH2O, p=0.004) during laparoscopic cholecystectomy.
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