Key result
Age-related vascular dysfunction contributes significantly to the pathogenesis of cognitive impairment and neurodegeneration, as highlighted by recent studies on hyperglycemia, blood pressure, and atherosclerosis.
Highlights the importance of understanding and treating age-related vascular disease given its significant contribution to mortality in the aging population.
The aging process prompts morphological, structural, and functional changes in the vasculature of our bodies These alterations occur in both health and disease and serve as mechanistic foundations for many cardiovascular and cerebrovascular diseases that are prevalent in the aging population Cardiovascular and cerebrovascular diseases are the most common cause of death among older people in the United States (Jaul and Barron, 2017), accounting for nearly 1/3rd of all deaths in the United States by the age of 65, and approximately 2/3rd of all deaths by the age of 85. With the percentage of the population over the age of 65 set to increase from 12% to 22% in the next 30 years (Ferruc et al., 2008), understanding and treating age-related vascular disease is paramount
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Petersen et al. (2024) conducted an editorial in Age-related neurodegeneration and cerebrovascular diseases. Age-related vascular dysfunction contributes significantly to the pathogenesis of cognitive impairment and neurodegeneration, as highlighted by recent studies on hyperglycemia, blood pressure, and atherosclerosis.
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