Key result
Participants in the upper tertile of Angiopoietin-2 had increased odds of elevated aortic pulse wave velocity compared to the lower tertile (OR 2.01; 95% CI 1.17-3.84; p=0.004).
Why the study?
Impaired angiogenesis may underlie aortic stiffness in diabetes, prompting investigation into the association between circulating angiogenic growth factors and aortic stiffness in type 2 diabetes patients without organ damage.
Is type 2 diabetes and circulating Ang-2 associated with increased aortic stiffness in patients without organ damage?
Case-Control (n=250)
Is type 2 diabetes and circulating Ang-2 associated with increased aortic stiffness in patients without organ damage?
Odds Ratio: 2.01 (95% CI 1.17–3.84)
p-value: p=0.004
In patients with type 2 diabetes, elevated circulating Ang-2 levels are associated with increased aortic stiffness, suggesting that impaired angiogenesis may contribute to early vascular changes.
Hypothesis-generating for angiogenesis in diabetic aortic stiffness; prospective studies needed before any clinical implications.
Objective. Impaired angiogenesis, measured as serum levels of angiogenic growth factors, may be among the mechanisms underlining aortic stiffness in diabetes patients. We studied the association between aortic stiffness and circulating angiogenic growth factors in type 2 diabetes (T2DM) patients without any organ damage. Methods. In a case-control design, aortic pulse wave velocity (PWV), augmentation index (AIx), and aortic blood pressures (BPs) were measured in 140 T2DM patients and 110 nondiabetic controls. Fasting blood samples were collected to measure the levels of angiopoietin- (Ang-) 1, Ang-2, and vascular endothelial growth factor-A (VEGF). Results. Compared to nondiabetes participants, T2DM patients had increased PWV ( 8.7 ± 1.5 vs. 7.6 ± 1.3 , p = 0.031 ), aortic pulse BP ( 58 ± 20 vs. 49 ± 17 , p = 0.011 ), Ang-2 (838 (473–1241) vs. 597 (274–1005), p = 0.018 ), and VEGF (72.2 (28–201.8) vs. 48.4 (17.4–110.1), p = 0.025 ) but reduced levels of AIx ( 21.7 ± 13.8 vs. 34 ± 12.9 , p < 0.001 ) and Ang-1 (33.1 (24.7–42.1) vs. 41.1 (30–57.3), p = 0.01 ). In all study participants, compared to those in the lower tertile, participants in the upper tertile of Ang-2 had increased odds of PWV (2.01 (1.17–3.84), p = 0.004 ), aortic systolic BP (1.24 (1.04–1.97), p = 0.011 ), and aortic pulse BP (1.19 (1.04–1.82), p = 0.041 ) but reduced odds of AIx (0.84 (0.71–0.96), p = 0.014 ) in multivariable-adjusted models. Conclusion. In our study population, increased circulating Ang-2 was associated with increased levels of aortic stiffness parameters.
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Agyekum et al. (2023) conducted a case-control in Type 2 diabetes (n=250). Upper tertile of Angiopoietin-2 vs. Lower tertile of Angiopoietin-2 was evaluated on aortic pulse wave velocity (PWV) (OR 2.01, 95% CI 1.17-3.84, p=0.004). Participants in the upper tertile of Angiopoietin-2 had increased odds of elevated aortic pulse wave velocity compared to the lower tertile (OR 2.01; 95% CI 1.17-3.84; p=0.004).
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