Key result
Plasma angiopoietin-2 was positively correlated with urine albumin-creatinine ratio (r = 0.301) and independently associated with albuminuria and systemic microinflammation in patients with chronic kidney disease.
Why the study?
Is plasma angiopoietin-2 associated with albuminuria and microinflammation in patients with chronic kidney disease stages 3 to 5?
Cross-Sectional (n=416)
No
Is plasma angiopoietin-2 associated with albuminuria and microinflammation in patients with chronic kidney disease stages 3 to 5?
Effect estimate: r = 0.301 (95% CI 0.211-0.386)
p-value: p=<0.0001
Plasma angiopoietin-2 is independently associated with albuminuria and markers of systemic microinflammation in patients with moderate to severe chronic kidney disease, suggesting a role in linking CKD to cardiovascular risk.
No takes yet. Share an insight, caveat, or question.
May link angiopoietin-2 to cardiorenal risk in CKD; hypothesis-generating, should not change practice pending trials.
Chang et al. (2013) conducted a cross-sectional in Chronic Kidney Disease (CKD) stages 3 to 5 (n=416). Plasma Angiopoietin-2 vs. Lower Angiopoietin-2 levels was evaluated on Correlation between urine albumin-creatinine ratio (ACR) and plasma Angiopoietin-2 (r = 0.301, 95% CI 0.211-0.386, p=<0.0001). Plasma angiopoietin-2 was positively correlated with urine albumin-creatinine ratio (r = 0.301) and independently associated with albuminuria and systemic microinflammation in patients with chronic kidney disease.
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