Key result
Depression symptoms were significantly associated with increased log hs-CRP (β = 0.011) in Hispanic/Latino youth, an association that was indirectly mediated by adiposity.
Why the study?
Inflammation contributes to chronic disease development, and it remains unknown whether depression and anxiety symptoms indirectly influence hs-CRP and PAI-1 through sleep duration and adiposity.
Cross-Sectional (n=1,466)
Yes
The association between depression symptoms and inflammation in Hispanic/Latino youth appears to be indirectly mediated by adiposity, suggesting that addressing both mental health and weight may be important for primary prevention of chronic inflammation.
Supports potential mediation by sleep/adiposity in depression-anxiety-inflammation pathways; hypothesis-generating, requires prospective confirmation before clinical consideration.
BACKGROUND: Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk. PURPOSE: To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference). METHODS: Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics. RESULTS: Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (β = .011, p = .047) but not PAI-1 (p = .285). Percentage body fat and waist circumference were positively related to depression symptoms (p = .026 and p = .028, respectively) and log hs-CRP (p < .001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI: .0006, .0119) and waist circumference (95% CI: .0004, .0109) were statistically significant. CONCLUSIONS: Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years.
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Nguyen‐Rodriguez et al. (2020) conducted a cross-sectional in General pediatric population (n=1,466). Depression symptoms vs. Lower depression symptoms was evaluated on Log high-sensitivity C-reactive protein (hs-CRP) (β = 0.011, p=0.047). Depression symptoms were significantly associated with increased log hs-CRP (β = 0.011) in Hispanic/Latino youth, an association that was indirectly mediated by adiposity.
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