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October 1, 2003Experimental and Clinical Endocrinology & Diabetes

Influence of an Antidiabetic Treatment with Sulfonylurea Drugs on Long-Term Survival after Acute Myocardial Infarction in Patients with Type 2 Diabetes

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Key result

Prior treatment with sulfonylureas did not significantly affect long-term survival after acute myocardial infarction in patients with type 2 diabetes compared to other antidiabetic treatments (p=0.53).

Why the study?

Does prior treatment with sulfonylurea drugs affect long-term survival in patients with type 2 diabetes after acute myocardial infarction?

Population

562 patients consecutively admitted to an intensive care unit with the diagnosis of acute myocardial…

Comparison

Sulfonylurea drugs prior to acute myocardial… vs Any other antidiabetic treatment, or no diabetes.

Design

Cohort

Follow-up

> 3 years

Authors

JMJuris J. MeierAugusta-Kranken-AnstaltSDS DeifußUniversitätsklinikum Knappschaftskrankenhaus BochumAKA. Klamann

Discussion

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Implication

No survival difference with prior sulfonylureas; leaves open optimal antidiabetic selection after MI in T2D.

Study Design

Type

Cohort (n=562)

Structured PICO

Does prior treatment with sulfonylurea drugs affect long-term survival in patients with type 2 diabetes after acute myocardial infarction?

P
Population
562 patients consecutively admitted to an intensive care unit with acute myocardial infarction, prospectively assessed for > 3 years.
E
Exposure
Sulfonylurea drugs (glibenclamide in all cases) prior to acute myocardial infarction.
C
Comparator
Any other antidiabetic treatment, or no diabetes.
O
Outcome
Long-term survivalhard clinical

Main Result

p-value: p=0.53

Prior treatment with sulfonylurea drugs does not negatively impact long-term survival after acute myocardial infarction in patients with type 2 diabetes.

Limitations

  • Requires larger prospective studies to clarify the findings
  • Small sample size (authors note larger prospective studies are necessary)

Cite This Study

Meier et al. (2003) conducted a cohort in Acute myocardial infarction and type 2 diabetes (n=562). Sulfonylureas vs. Any other antidiabetic treatment was evaluated on Long-term survival (p=0.53). Prior treatment with sulfonylureas did not significantly affect long-term survival after acute myocardial infarction in patients with type 2 diabetes compared to other antidiabetic treatments (p=0.53).

synapsesocial.com/papers/6a9958540b64aa5b17f0d72ahttps://doi.org/10.1055/s-2003-42725
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