Key result
Various treatment options including diet therapy, pharmacologic therapy, lipid apheresis, and liver transplantation are available for the optimal management of familial hypercholesterolemia.
This clinical review outlines various treatment and management strategies for familial hypercholesterolemia, including diet, pharmacotherapy, apheresis, and liver transplantation.
Affirms multiple options for familial hypercholesterolemia management; leaves open comparative trials to guide sequencing.
Familial hypercholesterolemia is an autosomally dominant disorder caused by various mutations in low-density lipoprotein receptor genes. This will lead to elevated levels of total and low-density lipoprotein cholesterol, which may in turn lead to premature coronary atherosclerosis and cardiac-related death. The symptoms are more severe in the homozygous type of the disease. Different options for the treatment of affected patients are now available. Diet therapy, pharmacologic therapy, lipid apheresis, and liver transplantation are among the various treatments. We clinically review the treatment and management strategies for the disease in order to shed light on the optimal management of familial hypercholesterolemia.
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Nemati et al. (2010) conducted a review in Familial hypercholesterolemia. Treatment and management strategies (diet, pharmacologic therapy, lipid apheresis, liver transplantation) was evaluated. Various treatment options including diet therapy, pharmacologic therapy, lipid apheresis, and liver transplantation are available for the optimal management of familial hypercholesterolemia.
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