Analysis of Polyethers by Isocratic HPLC with Universal Detectors. I. Optimization of Chromatographic Conditions

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Polyethylene glycols, their mono- and dimethyl ethers, and polypropylene glycols were analyzed by LAC with coupled density and RI detection on a C-18 column in methanol-water. Depending on the composition of the mobile phase, PEGs up to molecular weights of 3000 and PPGs up to molecular weights of 1000 could be separated. Peaks were identified using monodisperse oligomers as internal standards. Critical conditions for PEG were found at a mobile phase composition of MeOH:H2O 80: 20, which allowed a good separation of PPG.