PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

Mariaelvy Bianchini; Johan Duchêne; Donato Santovito; Maximilian J. Schloss; Maximilien Evrard; Holger Winkels; Maria Aslani; Sarajo K. Mohanta; Michael Horckmans; Xavier Blanchet; Michael Lacy; Philipp von Hundelshausen; Dorothee Atzler; Andreas J. R. Habenicht; Norbert Gerdes; Jaroslav Pelisek; Lai Guan Ng; Sabine Steffens; Christian Weber; Remco T. A. Megens

doi:10.1126/sciimmunol.aar3054

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Abstract

NCMs are present in tertiary lymphoid organs (TLOs) under inflammatory conditions in both mice and humans, and NCMs exhibit a PD-L1-dependent immunomodulatory function that promotes T cell apoptosis within TLOs. Our findings establish an unambiguous tool for the investigation of NCMs and shed light on their origin and function.

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Bianchini et al. (2019) studied this question.

synapsesocial.com/papers/6a9959b7545301b941054162 https://doi.org/10.1126/sciimmunol.aar3054

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PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

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Abstract

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PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

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