Novel 2,4‐diamino‐6‐methyl‐5‐ethynylpyrimidines were prepared via palladium catalyzed coupling of 2,4‐diamino‐5‐iodo‐6‐methyl‐pyrimidine with terminal acetylenes. The compounds were inhibitors of dihydrofolate reductase and showed in vitro activity against several species of opportunistic fungi and the protozoan Toxoplasma gondii.
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Jones et al. (1999) studied this question.
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