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N-Iodosuccinimide in trifluoroacetic acid and trifluoroacetic anhydride was found to be an excellent reagent for the conversion of 2,4-dialkoxy pyrimidines to 2,4-dialkoxy-5-iodopyrimidines. Iodination at C5-position of uracil and its derivatives was also accomplished with the above reagent.
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Das et al. (1988) studied this question.
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