Key result
Emerging strategies for neuroprotection in the perioperative period in neonatal patients with congenital heart disease are described to address neurodevelopmental deficits.
Why the study?
The perioperative period of neonatal cardiac surgery contributes to lifelong neurological injury, prompting the need to describe emerging neuroprotective strategies in neonatal CHD.
This review highlights emerging perioperative neuroprotective strategies to mitigate lifelong neurological injury in neonates undergoing surgery for congenital heart disease.
Congenital heart disease (CHD) includes defects of intrauterine cardiac development that result in alterations to the morphology and/or physiology of the heart, usually expressed early in fetal or postnatal life. This group represents one of the most common congenital anomalies of all living newborns worldwide. Neurodevelopmental deficits are a reality in patients with CHDs and may contribute to significant sequela and long-term morbidity beginning in infancy and extending into adulthood. There is general agreement that the perioperative period of neonatal cardiac surgery may be responsible for a significant burden of lifelong neurological injury in patients with CHDs. Recent research has advanced understanding of neurodevelopmental trajectories, factors that increase neurodevelopmental risk, and neuroprotective strategies for patients with these disorders. In the present study, we aim to describe the different emerging strategies for neuroprotection in the perioperative period in neonatal patients with congenital heart disease.
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Garcés‐Sánchez et al. (2025) conducted a review in Congenital heart disease. Neuroprotective strategies was evaluated. Emerging strategies for neuroprotection in the perioperative period in neonatal patients with congenital heart disease are described to address neurodevelopmental deficits.
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