Key result
Histopathological analysis with CD31 and CD34 immunohistochemistry successfully identified a rapidly growing hand nodule in a 76-year-old male as spindle cell angiosarcoma.
Case Report (n=1)
Highlights the importance of immunohistochemistry (CD31 and CD34) in distinguishing spindle cell angiosarcoma from other spindle-cell tumors for accurate diagnosis.
May aid accurate diagnosis of rare spindle-cell tumors; leaves open validation in larger cohorts.
Angiosarcoma is a rare, aggressive malignant tumor of vascular origin, often characterized by rapid growth and infiltrative behavior. While it commonly occurs in the skin, particularly on the scalp of elderly patients, it can also affect other regions. We present a case of a 76-year-old male with a rapidly growing, well-demarcated nodule on the dorsum of the hand, which was excised for pathological examination. Histopatho-logical analysis revealed spindle-shaped tumoral cells with a storiform pattern, poor vascularization, and immunohistochemistry positivity for CD31 and CD34. The case underscores the importance of distinguishing angiosarcoma from other spindle-cell tumors, such as leiomyosarcoma and atypical fibroxanthoma, and highlights the essential role of immunohistochemistry in achieving an accurate diagnosis. Early detection and appropriate surgical management are crucial for optimal outcomes in patients with this aggressive malignancy.
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Tinca et al. (2025) conducted a case report in Spindle cell angiosarcoma (n=1). Surgical excision and histopathological analysis was evaluated on Histopathological and immunohistochemical diagnosis. Histopathological analysis with CD31 and CD34 immunohistochemistry successfully identified a rapidly growing hand nodule in a 76-year-old male as spindle cell angiosarcoma.
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