When Follow-Up Shapes the Outcome

Q: What are the key findings of this study?

Protocol-directed surveillance angiography after AGENT paclitaxel-coated balloon treatment was associated with a higher 12-month MACE rate than clinical follow-up (26.9% vs 4.9%, P < 0.001).

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Coronary artery disease (in-stent restenosis and de novo small-vessel lesions) (n=500). Intervention: Protocol-directed surveillance angiography after AGENT paclitaxel-coated balloon angioplasty vs. Follow-up without routine surveillance angiography. Primary outcome: Major adverse cardiovascular events (MACE) at 12 months (p=<0.001).

Sara Malakouti; Bernardo Cortese

doi:10.1016/j.jacasi.2026.06.029

September 1, 2026JACC AsiaOpen Access

When Follow-Up Shapes the Outcome

View Full Paper

Ask AI

Bookmark

Share

Key result

Surveillance angiography linked to ~5.5-fold higher 12-month MACE vs clinical follow-up after AGENT DCB.

P<0.001
n=500

PICO

P

Population

500 predominantly Chinese patients with in-stent restenosis or de novo small-vessel coronary lesions (58% diabetes, 62.6% multivessel disease) across 9 centers, followed for 12 months.

E

Exposure / Comparator

Protocol-directed surveillance angiography after AGENT paclitaxel-coated balloon angioplasty vs Follow-up without routine surveillance angiography

O

Primary Outcome

Major adverse cardiovascular events (MACE) at 12 months, p=<0.001

Main Result

Absolute Event Rate: 26.9% vs 4.9%

p-value: p=<0.001

Limitations

In >80% of cases, target lesion revascularization was performed in angiographically nonsignificant lesions (<70% diameter stenosis) without known symptom status
Lower technical success (86%) and higher late lumen loss (0.17 mm) in de novo lesions highlighting variability in operator training and lesion preparation
Observational registry design where routine surveillance angiography substantially inflated repeat revascularization rates without physiological confirmation

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Reveals higher repeat revascularization with routine surveillance angiography after drug-coated balloon treatment, highlighting how follow-up methods alter outcomes.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Malakouti et al. (2026) conducted an editorial in Coronary artery disease (in-stent restenosis and de novo small-vessel lesions) (n=500). Protocol-directed surveillance angiography after AGENT paclitaxel-coated balloon angioplasty vs. Follow-up without routine surveillance angiography was evaluated on Major adverse cardiovascular events (MACE) at 12 months (p=<0.001). Protocol-directed surveillance angiography after AGENT paclitaxel-coated balloon treatment was associated with a higher 12-month MACE rate than clinical follow-up (26.9% vs 4.9%, P < 0.001).

synapsesocial.com/papers/6a996593636c6408cfa7f8bf https://doi.org/10.1016/j.jacasi.2026.06.029

View Full Paper

Ask AI

Bookmark

Share

When Follow-Up Shapes the Outcome

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

When Follow-Up Shapes the Outcome

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading