Two patients with first trimester abortion and idiopathic cold agglutinin syndrome due to cold auto‐antibodies of the IgM and IgG immunoglobulin classes are reported. Sucrose gradient ultracentrifugation and 2‐mercapto‐ethanol treatment indicated the presence of IgM as well as IgG cold agglutinins. The possible relationship between the abortions and these cold agglutinins is discussed.
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Mygind et al. (1972) studied this question.
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