A Pilot Study Scouting the Association of Hotair Genetic Polymorphisms With Gastric Cancer Risk in Some Egyptian Patients

Gastric cancer is one of the prevalent malignant tumors all over theworld. In the current study we aimed at elucidating a possible correlationbetween LncRNA-HOTAIR polymorphisms rs7958904 G>C andrs874945 G>A and risk of developing gastric cancer in Egyptian patients.Blood samples were collected from controls and patients. We performedreal-time polymerase chain reaction (RT-PCR) for genotyping of the twovariant alleles at the SNPs sites of HOTAIR gene in all subjects. As regardrs7958904 SNP, there was statistically significant higher mutant genotypeCC and Mutant C allele among gastric cancer patients and as regardrs874945 SNP, there was statistically significant higher mutant genotypeAA and Mutant A allele among gastric cancer patients. As regardrs874945 SNP, the mutant genotype AA and the Mutant A allele werestatistically significantly higher in Positive H. pylori patients than negativeH. pylori patients. In Conclusion, the mutant genotypes (CC and AA) ofrs7958904and rs874945 SNPs of LncRNA-HOTAIR gene predominate ingastric cancer patients that would displayed their impact in increasing therisk of developing gastric cancer in Egyptian patients, while the wildgenotypes (GG and GG) predominate in controls which support ourhypothesis.