Assessment of Provocative Inflammatory Role of Tristetraprolin and Tumor Necrosis Factor Alpha Genes Expression in Chronic Kidney Disease

Renal inflammation is a prominent feature of chronic kidney disease (CKD).The determinants of renal function decay are not completely comprehended.Tristetraprolin (TTP) and tumor necrosis factor (TNFα) are immune mediators and affect renal inflammation.This study was planned to estimate gene expression of both TTP and TNF-α in CKD.One hundred fifty subjects were rolled in this study (55 CKD patients with hypertension, 45 CKD patients without hypertension and 50 healthy subjects).Renal functions, lipid profile & blood glucose were estimated from serum.TTP and TNF-α genes expression were assessed from whole blood samples by real time PCR.The results showed that TTP expression was significantly down-regulated while TNF-α was up-regulated in CKD patients with and without hypertension compared with healthy controls.It could be concluded that TTP and TNF-α may have a provocative inflammatory role in renal illness and may be utilized as promising biomarkers and therapeutic focus in CKD.