Key result
General anesthesia significantly increased postoperative serum IL-6 levels at 6 hours compared to spinal anesthesia (2.66 pg/ml vs 1.79 pg/ml, p<0.05) in patients undergoing urooncologic surgery.
Why the study?
Does general anesthesia compared to spinal anesthesia affect serum cytokine levels (IL-2, IL-4, IL-6) in patients undergoing urooncologic surgery?
RCT (n=44)
Open-label
Sealed envelope
No
Does general anesthesia compared to spinal anesthesia affect serum cytokine levels (IL-2, IL-4, IL-6) in patients undergoing urooncologic surgery?
Absolute Event Rate: 2.66% vs 1.79%
p-value: p=<0.05
General anesthesia may induce a greater inflammatory response, as evidenced by elevated IL-6 levels, compared to spinal anesthesia in patients undergoing urooncologic surgery.
Spinal anesthesia may attenuate early IL-6 elevation versus general anesthesia; extends RCT evidence on anesthetic effects on postoperative inflammation in urooncologic surgery.
Objectives: In this study, it was aimed to compare effects of general anesthesia and spinal anesthesia on the immune system via serum cytokines interleukine 2 (IL-2), interleukine 4 (IL4), interleukine 6 (IL-6) in urologic cancer patients. Methods: Forty-four, ASA physical status I–II patient, who were scheduled for urooncologic surgery with spinal or general anesthesia enrolled to the study. Demographic parameters, heart rate and mean blood pressure values were recorded. Venous blood samples were taken at preoperative period and postoperatively 6th hours to determine IL-2, IL-4 and IL-6 levels. Results: There was no statistical significance between groups among heart rate and mean blood pressure values. There were no significant difference in preoperative IL-2, IL-4, IL-6 and postoperative IL-2, IL-4 levels between groups, however postoperative IL-6 levels were significantly increased in general anesthesia group compared with spinal anesthesia group (p<0.05). Conclusions: Preferred anesthetic method might influence inflammatory response in addition to surgery in cancer patients undergoing urooncologial surgery.
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Aydoğan et al. (2013) conducted an RCT in Urologic cancer (urooncologic surgery) (n=44). General anesthesia vs. Spinal anesthesia (12.5-15 mg heavy bupivacaine) was evaluated on Postoperative serum IL-6 levels at 6 hours (pg/ml) (p=<0.05). General anesthesia significantly increased postoperative serum IL-6 levels at 6 hours compared to spinal anesthesia (2.66 pg/ml vs 1.79 pg/ml, p<0.05) in patients undergoing urooncologic surgery.
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