Repeatability and Reproducibility of Pancreas Volume Measurements Using MRI

Figures

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  Figure 1. Measurements of pancreas volume are repeatable. Two or three repeat MRIs were performed on the same day in individuals with and without T1D (dashed and solid lines, respectively). Repeat measurements of pancreas volume (a) and pancreas volume index (b) are shown for each subject. Pancreas volume index was calculated by dividing the pancreas volume by the subject’s weight. Intraclass correlation coefficients (ICC) were reported with a 95% confidence interval.

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  Figure 2. Measurements of pancreas volume between two readers are reproducible. Two board-certified radiologists independently outlined the pancreas of 30 different individuals (31 total scans). Correlation between measurements of pancreas volume (a) and pancreas volume index (c) between the two readers is shown. Bland–Altman plots displaying the differences in measurements between readers plotted against the average measurement taken for each subject are shown for both pancreas volume (b) and pancreas volume index (d). Pancreas volume index was calculated by dividing the pancreas volume by the subject’s weight. ICCs were reported with a 95% confidence interval.

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  Figure 3. Outlines of pancreas by two readers of the same images overlap. The pancreas from a representative subject (Dice coefficient = 0.77) was outlined by two board-certified radiologists across eight alternating MRI slices of the pancreas. The overlap between the two readers’ pancreas outlines is shown in the bottom row and zoomed in for clarity. Regions of agreement are shown in bright white, while gray regions denote regions of non-overlap. The average Dice coefficient was 0.77 for the 31 scans analyzed.

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  Figure 4. Stomach volume did not affect measurements of pancreas volume. (a) Correlation between measurements of pancreas volume and total stomach volume in individuals whose MRI data sets contained the entire stomach volume within the field of view (R2 = 0.009). (b) Individuals who had longitudinal measurements of pancreas and stomach volume. Representation of an individual with low stomach volume (c) and in an apparent fed state (d).