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February 7, 2025TomographyOpen Access

Multiparametric Magnetic Resonance Imaging Findings of the Pancreas: A Comparison in Patients with Type 1 and 2 Diabetes

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Authors

MHMayumi HigashiMTMasahiro TanabeKTKatsuya Tanabe

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Overview

Prospective comparative study demonstrates distinct pancreatic structural and functional alterations in diabetes subtypes, indicating distinct underlying pathophysiological mechanisms.

Key Points

  • To evaluate and compare pancreatic structural, functional, and compositional alterations on multiparametric 3-T MRI across patients with type 1 diabetes, type 2 diabetes, and non-diabetic controls.
  • Prospective cohort of patients with type 1 diabetes (n = 7) and type 2 diabetes (n = 54) compared against retrospectively enrolled non-diabetic controls (n = 21) undergoing upper abdominal 3-T MRI.
  • Evaluated imaging metrics including pancreatic anteroposterior diameter, fat-suppressed T1-weighted signal intensity ratio, apparent diffusion coefficient (ADC), T1 relaxation times, proton density fat fraction (PDFF), and cine-dynamic MRCP juice secretion grades using ANOVA and Kruskal–Wallis tests.
  • Pancreatic anteroposterior diameters were significantly smaller in type 1 diabetes than in type 2 diabetes (p < 0.05), with significantly lower signal intensity ratios on fat-suppressed T1WI (p < 0.001) and lower pancreatic juice flow secretion grades (p = 0.019) compared to controls.
  • Mean pancreatic ADC and T1 values were significantly higher in type 1 diabetes compared with type 2 diabetes (p < 0.01) and control participants (p < 0.05).
  • Mean pancreatic proton density fat fraction was significantly higher in patients with type 2 diabetes compared with controls (p = 0.029).

Cite This Study

Higashi et al. (2025) studied this question.

synapsesocial.com/papers/6a87e84170098fa105bb5ecehttps://doi.org/10.3390/tomography11020016
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