Key result
Amantadine treatment resulted in an 80% improvement in severe tardive dyskinesia symptoms that had developed after risperidone withdrawal in a 32-year-old woman.
Case Report (n=1)
Amantadine successfully treated severe tardive dyskinesia presenting as tongue protrusion following risperidone withdrawal in a young woman.
Alerts clinicians to TD risk after antipsychotic withdrawal; case report leaves open mechanisms and management of isolated tongue protrusion.
Tardive dyskinesia (TD) is one of the most serious and disturbing side-effects of dopamine receptor antagonists. It affects 20-50% of patients on long-term antipsychotic therapy. The pathophysiology of TD remains poorly understood, and treatment is often challenging. Here, we present a 32-year-old woman presenting with a 9-month history of TD occurring after risperidone withdrawal, and characterized almost exclusively by tongue protrusion. After being seen by different specialties and undergoing multiple investigations, she was eventually correctly diagnosed with TD by a specialist team and successfully treated with amantadine. Vigilance and awareness of this condition and its risk factors are required to make the correct diagnosis, especially in cases with unusual presentations caused by atypical antipsychotics, and treatment can be challenging.
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Alblowi et al. (2015) conducted a case report in Tardive dyskinesia (n=1). Amantadine was evaluated on Improvement in tardive dyskinesia symptoms. Amantadine treatment resulted in an 80% improvement in severe tardive dyskinesia symptoms that had developed after risperidone withdrawal in a 32-year-old woman.
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